Some researchers at Johns Hopkins have taken the AHP-1200CPV thermoelectric cold plate (Peltier cold plate) and are cooling protein crystallization in Teflon trays with a solution in them. They’ve used the remote sense feature by drilling a hole in Teflon tray and installing the sensor in there. Using it with internal sensor and the auto-tuning feature they have gotten the control they needed. The secret may have been in how well the Teflon tray is contacting the 2″ X 3″ plate, machined perfectly flat.
Cooling objects with concave bottoms minimizes the contact area and diminishes the cooling effectiveness.